Banca de QUALIFICAÇÃO: ANDRE ALENCAR MOREIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ANDRE ALENCAR MOREIRA
DATE: 13/03/2024
TIME: 08:30
LOCAL: Faculdade de Medicina - Campus Barbalha
TITLE:

CHARACTERIZATION OF THE MICROBIOTA ON THE EDGE OF ULCERS OF PATIENTS WITH AMERICAN TEGUMENTARY LEISHMANIASIS

 

KEY WORDS:

American Cutaneous Leishmaniasis. Cutaneous Leishmaniasis; Bacterial and Fungal
Infection; Inflammation; Healing; Treatment.

PAGES: 84
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

The American Cutaneous Leishmaniasis - ACL is an infectious, non-contagious disease, caused by different species of protozoa of the genus Leishmania, which affects the skin and mucous membranes. Leishmania is a protozoan belonging to the Trypanosomatidae family, na obligatory intracellular parasite of cells of the mononuclear phagocytic system, with two main forms: a flagellate or promastigote, found in the digestive tube of the insect vector, and another aflagellate or amastigote, observed in the tissues of vertebrate hosts. The vectors of ACL are insects called sandflies, belonging to the Order Diptera, Family Psychodidae, Subfamily Phlebotominae, Genus Lutzomyia, popularly known, depending on the geographic location, as sandfly, armadillo, birigui, among others. Therefore, the guiding question of this research aims to discover whether the use of antibiotics and/or antifungals, in addition to the usual pentavalent antimony (Glucantime®), regularly used, is effective in treating the disease? After a quick search in the databases: Capes Journal Portal, Medical Literature Analysis and Retrieval System Online (Medline) and Latin American and Caribbean Literature in Health Sciences (Lilacs), it was found that there were no studies that address co-infection by ACL in our midst. In this way, the dissertation proposal presented here fills a gap in studies, seeking to obtain knowledge that contributes to a better therapeutic approach to the disease. In our understanding, this research is justified by its originality and by the understanding that when dealing with the topic presented now, we inevitably enter the universe of intellectual discoveries, which deal with the characterization of ACL, from the perspective of reducing treatment time, until then invisible. In this way, based on the problem and justification, the objectives of this research were outlined. The general objective is: To characterize the microbiota on the edge of ulcers in patients with American Cutaneous Leishmaniasis. With a view to understanding the functioning of the bacterial and fungal microbiota on the edges of ulcers in patients with American Cutaneous Leishmaniasis; determine the sensitivity/resistance profile to antibiotics of the bacterial microbiota isolated from the edges of ulcers of patients with American cutaneous leishmaniasis; demonstrate the fungal etiology of ulcer edges in patients with American cutaneous leishmaniasis; compare the microbiota of healthy skin with the microbiota of the edges of ulcers in patients with American cutaneous leishmaniasis; evaluate the variation in the microbiota of ulcer edges in patients with American cutaneous leishmaniasis undergoing treatment; to point out the healing time of ulcers in patients with American cutaneous leishmaniasis undergoing treatment with the resident microbiota. It is, therefore, an observational, analytical, prospective, and transversal study, since it aims to study a specific situation of a given population, evaluating the state of the art of a situation, as well as carrying out na assessment based on the state of each individual that makes up a population, or sample.

COMMITTEE MEMBERS:
Presidente - CLAUDIO GLEIDISTON LIMA DA SILVA
Interna - MARIA DO SOCORRO VIEIRA DOS SANTOS
Externa à Instituição - RACQUEL OLIVEIRA DA SILVA SOUZA - F.M.NASSAU