Banca de DEFESA: SIMONE FERREIRA LÔBO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : SIMONE FERREIRA LÔBO
DATE: 08/07/2024
TIME: 14:00
LOCAL: Sala de Videoconferência - Faculdade de Medicina (UFCA)
TITLE:

SEROPREVALENCE OF VISCERAL LEISHMANIASIS IN BODIES FROM THE DEATH VERIFICATION SERVICE (SVO) OF BARBALHA, CEARÁ, BRAZIL.

KEY WORDS:

Leishmaniasis, Visceral; Leishmania; Seroepidemiologic Studies.

PAGES: 69
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUBÁREA: Saúde Pública
SUMMARY:

Visceral Leishmaniasis (VL), also known as Kala-azar, is an infectious, non-contagious disease characterized as a Neglected Tropical Disease (NTD). It has the most severe clinical form of leishmaniasis and, when left untreated, up to 90% of cases can progress to death due to parasitic involvement of several organs, especially bone marrow, spleen and liver. Given this scenario, the importance of the Death Verification Service (SVO) stands out as a surveillance service capable of determining the Cause of Death naturally with or without medical assistance, especially those under epidemiological investigation. The present study aimed to evaluate the seroprevalence of Visceral Leishmaniasis in bodies from the Death Verification Service in the city of Barbalha, Ceará, Brazil. This is an observational, descriptive, cross-sectional study with uncontrolled prevalence, carried out from January to April 2024. After the legal representative signed the informed consent form, the sociodemographic and clinical epidemiological profile of the post-mortem bodies was collected, and then the subclavian vein was punctured to obtain plasma through a centrifuge to perform the immunochromatographic test for qualitative detection of antibodies to parasites of the Leishmania donovani complex. Simultaneously, complementary immunochromatographic tests for COVID-19, Syphilis, HCV, HBV, and HIV were performed. This study was approved by the Research Ethics Committee of the Federal University of Cariri – UFCA, Barbalha, CE, Brazil, under registration CAAE 76885323.7.0000.5698. A total of 223 samples were analyzed, of which it was observed that there was no seroprevalence for VL (0%) in the UFCA SVO, however, for COVID-19, Syphilis, HCV, HBV and HIV, there was a low seroprevalence rate, with values of 5.38%, 2.69%, 0.89%, 0.44% and 0%, respectively. When associated with the positivity of the immunochromatographic test for syphilis with the sociodemographic characteristic of no professional occupation, a statistically significant value was observed (p = 0.006). According to the study, the results suggest that although the SVO coverage region brings together cities endemic for human VL, the post-mortem bodies that were admitted during the sample collection period did not present positivity in the immunochromatographic test for VL, and no confirmatory clinical history for visceral leishmaniasis was identified. It can be concluded that the cases of VL that resulted in death in the areas covered by the study were clarified as to the Cause of Death, and it was not necessary to activate the UFCA Death Verification Service.

COMMITTEE MEMBERS:
Presidente - CLAUDIO GLEIDISTON LIMA DA SILVA
Externo à Instituição - LUIS RAFAEL LEITE SAMPAIO - URCA
Interna - MARIA DO SOCORRO VIEIRA DOS SANTOS
Externa à Instituição - RACQUEL OLIVEIRA DA SILVA SOUZA - F.M.NASSAU